PATHOGENETIC CORRECTION OF RENAL FAILURE WITH ACUTE OBSTRUCTIVE CHOLESTASIS

Yudin Aleksey Alexandrovich, Urologist, Mordovia Republican Clinical Hospital; postgraduate student, sub-department of general surgery and anesthesiology named after N. I. Atyasov, Mordovia State University bamed after N. P. Ogarev, belyaevan@ mail.ru
Belyaev Alexander Nazarovich, Doctor of medical sciences, professor, head of sub-department of general surgery and anesthesiology named after N. I. Atyasov, Mordovia State University bamed after N. P. Ogarev, belyaevan@ mail.ru

616.005.1-10

In experiment on 40 anesthetized (45 mg/kg) dogs it was modelled obstructive jaundice imposing ligation of the common bile duct. At height of biochemical infringements (3 days) it was made decompression bile duct by the subsequent intravenous and intraportal infusions mexidol (6,45 mg/kg). Results have shown, that intravenous and to degree intraportal infusions mexidol promoted essential normalisation of functional activity of a liver and secretory function of kidneys.

obstructive jaundice, liver, kidneys, mexidol, intraportal infusions.